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KMID : 0854720090290030194
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Korean Journal of Asthma, Allergy and Clinical Immunology
2009 Volume.29 No. 3 p.194 ~ p.199
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Intranasal Administration of Unmethylated CpG with Cockroach Antigen Prevents the Development of Cockroach-Induced Allergic Inflammation
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Sohn Jung-Ho
Kim Joo-Young
Lee Jae-Hyun
Lee Yong-Won
Hong Chein-Soo
Park Jung-Won
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Abstract
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Background: Unmethylated CpG can induce Th1 and regulatory T cell immune responses and may modulate ovalbumin-induced mouse allergic asthma. However, the effects of CpG in a cockroach allergen asthma model have not yet been elucidated.
Objective: To evaluate whether unmethylated CpG can prevent the development of indoor allergen-induced allergic asthma.
Methods: Effects of CpG were evaluated using a cockroach allergen-induced mouse model. CpG and Blattella germanica (CR) allergen were co-administered intranasally, and methacholine airway hyperresponsiveness (MCh-AHR), inflammatory cells and cytokine profiles in BAL fluid and lung histology were evaluated.
Result: Co-administration of CpG with CR allergen can prevent the development of MCh-AHR and allergic inflammation in a CR-induced asthma mouse model. Eosinophils, lymphocytes, macrophages and neutrophils in BAL fluid were decreased by the co-administration of unmethylated CpG in an OVA-induced asthma model. The expression of IL-5, IL-13 and IFN-γ in BAL fluid was attenuated by the CpG. Peribronchial, perivascular inflammation, and goblet cell hyperplasia in respiratory epithelium were also markedly attenuated by the CpG.
Conclusion: These findings suggest that unmethylated CpG may have role in the immune modulation of allergic asthma induced by indoor allergens.
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KEYWORD
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Cockroach, CpG, Asthma
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